Research
Scientific articles on peptide research, documentation, purity, and traceability.
Alpha Research
Metabolism
SLU-PP-332: ERRα/ERRβ/ERRγ Pan-Agonist Activity, PGC-1α/TFAM Upregulation, and Exercise-Mimetic Research
Pharmacological analysis of SLU-PP-332 as a pan-agonist of ERRα (EC50 ~99 nM), ERRβ (EC50 ~48 nM), and ERRγ (EC50 ~14 nM). PGC-1α coactivation mechanism, TFAM (2.3x), NRF1 (1.8x), and CYTC (2.1x) upregulation in C2C12 myotubes. Rodent in vivo data: 70% endurance time increase and VO2 max +44% at 35 mg/kg/day for 28 days (n=10).
Alpha Research
Metabolism
AOD-9604 (hGH Fragment 176-191): β3-Adrenoceptor-Mediated Lipolysis, Adipocyte Selectivity, and Metabolic Research Data
Pharmacological analysis of AOD-9604 as a C-terminal hGH fragment with β3-AR-mediated lipolytic activity (EC50 ~1.0–2.5 nM in rat adipocytes) independent of the GHR/IGF-1 axis. ATGL/HSL/PLIN1 mechanism, PKA/cAMP regulation, and adipocyte selectivity data in ob/ob models.
Alpha Research
Metabolism
Retatrutide (LY3437943): GLP-1R/GIP-R/GCG-R Triple Agonism, Receptor Binding Affinities, and Phase 2 Clinical Data
Pharmacological analysis of retatrutide (LY3437943) as a unimolecular triple agonist at GLP-1R (Ki ~0.5 nM), GIP-R (Ki ~2.0 nM), and GCG-R (Ki ~0.9 nM). Gs/cAMP/PKA and β-arrestin mechanisms, BAT thermogenesis, and hepatic oxidation. Phase 2 data (NCT04855164): 17.5% body weight reduction at 12 mg/week over 24 weeks (n=71).
Alpha Research
cellular longevity
Melanotan II: Research on Pigmentation and Melanocortin Receptors
Melanotan II is a peptide investigated for its potential in regulating skin pigmentation through melanocortin receptors. This article will explore its mechanisms of action and relevance in preclinical research models.
Alpha Research
cellular longevity
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper): Copper Chelation Chemistry, MMP Modulation, TGF-β1 Activation, and Pleiotropic Tissue Remodeling
Comprehensive biochemical analysis of GHK-Cu: copper-tripeptide complex stability, TGF-β1/Smad2/3 activation, differential MMP-1/TIMP-1/TIMP-2 regulation, Wnt/β-catenin signalling, and implications for tissue remodeling research.
Alpha Research
Growth hormone
CJC-1295 + Ipamorelin: Synergistic GHRH/GHS-R1a Dual Axis Stimulation and Mechanistic Research Rationale
Mechanistic analysis of CJC-1295 and ipamorelin co-administration: convergence at the somatotroph, cAMP/PKA/CREB signaling, somatostatinergic tone modulation, and comparative pharmacokinetic data for preclinical research models.
Alpha Research
Growth hormone
Tesamorelin: Trans-2-Hexadecenoyl GHRH Analogue, GH Secretion Kinetics, and Visceral Adiposity Research Data
Technical review of tesamorelin as an N-terminally modified GHRH(1–44) analogue with trans-2-hexadecenoyl group: pharmacokinetics (t½ ~26 min SC), GHRH-R activation, GH/IGF-1 AUC data, and visceral fat reduction data from phase 3 clinical trials (mean 15% VAT reduction, p<0.001).
Alpha Research
Growth hormone
Sermorelin Acetate: GHRH(1-29) Analogue, Pituitary Somatotroph Activation, and Research Pharmacokinetics
Technical review of sermorelin acetate as a GHRH(1–29) analogue: GHRH-R receptor activation mechanism via cAMP/PKA/CREB, pituitary somatotrophs, GH secretion kinetics (t½ ~10–12 min), IGF-1 response, and clinical study data in adult GH-deficient subjects.
Alpha Research
Growth hormone
CJC-1295 with DAC: GHRH Receptor Binding, Albumin Conjugation Mechanism, and Extended Half-Life Pharmacokinetics
Technical analysis of CJC-1295/DAC: covalent albumin conjugation mechanism via Drug Affinity Complex group, extended release kinetics (t½ ~6–8 days), GHRH-R receptor activation, and GH/IGF-1 AUC data from human clinical studies.
Alpha Research
Growth hormone
Ipamorelin: GHS-R1a Binding Selectivity, Pulsatile GH Secretion, and Pharmacokinetic Profile
Clinical analysis of ipamorelin as a selective GHS-R1a agonist: cAMP/PKA signaling mechanism in pituitary somatotrophs, GH pulse architecture, pharmacokinetic profile (t½ ~2h), and IGF-1 response data from preclinical models.
Alpha Research
Recovery
Peptides in Musculoskeletal Repair Research: Tendon, Muscle, and Ligament Models
Mechanistic review of BPC-157, TB-500, and GHK-Cu in preclinical musculoskeletal repair models: FAK/VEGFR2 signaling, actin sequestration, TGF-β1/MMP remodeling, and rodent pharmacokinetic parameters.
Alpha Research
Fundamentals
Classification of Research Peptides by Mechanism Class and Receptor Profile
Systematic classification of research peptides by mechanism of action, target receptor subtype, and signaling consequences: GPCR agonists, integrin modulators, mitochondrial peptides, antimicrobials, and GH secretagogues, with pharmacological profile data for each category.