Research

KPV (Lys-Pro-Val): α-MSH C-Terminal Fragment and MC1R-Mediated Anti-Inflammatory Signaling

Mechanistic analysis of KPV (Lys-Pro-Val), the C-terminal tripeptide of α-melanocortin (α-MSH): MC1R affinity, cAMP/PKA/CREB signaling, NF-κB inhibition, and IL-1β/TNF-α production reduction in RAW264.7 macrophages and experimental colitis models in rodents.