Research

TB-500 and Cell Migration: G-Actin Binding, Integrin Signaling, and Wound Healing Models

Mechanistic analysis of TB-500 (Thymosin β4) activity in cell migration: Tβ4:G-actin complex dynamics, Rac1-mediated cell polarization, integrin α5β1 signaling on fibronectin, and quantitative data from scratch assays, transwell assays, and wound healing models in rodents.