Research
Scientific articles on peptide research, documentation, purity, and traceability.
Alpha Research
Longevity
Selank vs Semax: Comparative Neuropeptide Profiles, Receptor Targets, and Cognitive Research Differentiation
Selank modulates GABA-A and induces BDNF; Semax activates ACTH/melanocortin pathways with effects on BDNF, dopamine, and hippocampal plasticity. Mechanistic comparison, anxiety vs cognition research models, and experimental parameters.
Alpha Research
Longevity
NAD+ Precursor Pharmacokinetics: Comparative Bioavailability of NR, NMN, and Direct NAD+ Formulations
NR enters cells via ENT1/2 and is phosphorylated to NMN intracellularly; NMN is transported via Slc12a8; direct NAD+ requires extracellular degradation. Comparative analysis of tissue kinetics, brain penetration, and research endpoints.
Alpha Research
Metabolism
AOD-9604 vs Full-Length hGH: Adipocyte-Selective β3-AR Interactions vs Systemic GHR Signaling — Differentiated Metabolic Profiles
Mechanistic comparison of AOD-9604 and full-length hGH: GHR displacement assay confirming >12,500-fold selectivity differential, comparative glycerol release dose-response in 3T3-L1 adipocytes, depot-selective DEXA fat mass data in Zucker rats, insulin tolerance testing showing divergent HOMA-IR profiles, and onset kinetics distinguishing direct cAMP signaling from transcription-dependent GHR pathway.
Alpha Research
Metabolism
Triple vs Dual vs Mono Agonism: Comparative Receptor Pharmacology of Retatrutide, Tirzepatide, and Semaglutide
Direct pharmacological comparison of retatrutide (GLP-1R Ki ~0.5/GIP-R ~2.0/GCG-R ~0.9 nM, t½ ~144h), tirzepatide (GIP-R Ki ~0.4/GLP-1R ~2.0 nM, t½ ~120h), and semaglutide (GLP-1R Ki ~0.38 nM, t½ ~168h). Gs/β-arrestin pathway differentiation per receptor, STEP 1/SURMOUNT-1/GZGI data, and mechanistic GCG-R contributions to thermogenesis and hepatic oxidation.
Alpha Research
cellular longevity
Hydrolyzed Collagen vs Bioactive Peptides: Which is More Effective?
This article compares hydrolyzed collagen and bioactive peptides, focusing on their effectiveness in preclinical models. Through a review of the scientific literature, their mechanisms of action and applications in research are explored.
Alpha Research
Growth hormone
Tesamorelin vs Sermorelin: Structural Stability, GHRH-R Binding Kinetics, and Comparative Pharmacokinetic Profiles
Mechanistic comparison of tesamorelin and sermorelin: trans-3-hexenoyl structural modifications conferring DPP-IV stability, GHRH-R binding kinetics, comparative pharmacokinetic parameters (t½, bioavailability, Cmax), and GH AUC response in research models.
Alpha Research
Growth hormone
Ipamorelin vs Sermorelin: Receptor Selectivity, GH Pulse Architecture, and IGF-1 Response Profiles
Head-to-head technical comparison of ipamorelin (GHS-R1a agonist, ghrelin class) versus sermorelin (GHRH-R agonist, GHRH class): differential signaling mechanisms, receptor selectivity, GH pulse architecture, comparative pharmacokinetics, and IGF-1 responses in preclinical and clinical models.