Research
Scientific articles on peptide research, documentation, purity, and traceability.
Alpha Research
Science
Critical Appraisal of Peptide Research Literature: Study Design Hierarchy, Confounders, and Evidence Quality Scoring
Methodological guide for researchers on critically appraising peptide studies: evidence hierarchy (RCT vs. preclinical), common biases, endpoint evaluation, CoA interpretation, and statistical considerations.
Alpha Research
Science
Peptides in Clinical Development: Phase 1-3 Pipeline, Endpoint Design, and Key Regulatory Milestones
Overview of peptide clinical development: Phase 1-3 trial design, primary/secondary endpoint selection criteria, FDA/EMA regulatory milestones, and the current therapeutic peptide pipeline.
Alpha Research
Science
FDA Regulatory Framework for Research Peptides in 2026: 503A/503B Compounding, GLP-1 Scheduling, and Research-Use Documentation
Analysis of FDA's regulatory framework for research peptides in 2026: 503A/503B designations, the GLP-1R agonist transition from Candidate List to Category 1, and documentation requirements for research distributors.
Alpha Research
Stacks
Cognitive Research Stack: Selank + NAD+ — GABAergic Modulation and NAD+-Dependent Neuronal Energy Research
Analysis of Selank (tuftsin-analogue heptapeptide with GABAergic modulation and BDNF induction) and NAD+ (SIRT1/3 sirtuins, neuronal mitochondrial biogenesis, CD38 pathway) as a research combination in preclinical cognitive models.
Alpha Research
Stacks
Metabolic Stack: Peptide Combinations in Metabolic Research — GLP-1R/GIP-R Agonism, Lipolytic Agents, and Mitochondrial Activators
Pharmacological analysis of metabolic peptide combinations: dual GLP-1R/GIP-R agonism (Tirzepatide, Retatrutide), lipolytic fragments (AOD-9604), and exercise mimetics (SLU-PP-332) in adiposity and mitochondrial function research models.
Alpha Research
Stacks
GHK-Cu + NAD+: Convergent Pathways in Cellular Senescence Research, Collagen Matrix Maintenance, and Metabolic Homeostasis
Analysis of GHK-Cu (MMP/TIMP modulation, TGF-β1 activation) and NAD+ (sirtuin substrate, PARP1-mediated DNA repair) as a research combination in cellular senescence and metabolic homeostasis models.
Alpha Research
Stacks
BPC-157 + TB-500 + GHK-Cu: Mechanistic Complementarity in Tissue Repair, Angiogenesis, and Matrix Remodeling
Mechanistic analysis of BPC-157 (VEGF/FAK signaling), TB-500 (G-actin regulation, cell migration), and GHK-Cu (collagen synthesis, metalloproteinases) as a research combination in preclinical tissue repair models.
Alpha Research
Stacks
Documented Synergies in Peptide Research: Complementary Mechanisms, Timing Rationale, and Stack Evidence Quality Assessment
Three evidence quality tiers for peptide synergy: Tier 1 (formal CI analysis, BPC-157+TB-500 CI~0.72 in wound models), Tier 2 (mechanistic plausibility without CI analysis), Tier 3 (rationale only). Timing considerations for wound repair stacks and combination evaluation framework.
Alpha Research
Stacks
Peptide Combination Research: Pharmacokinetic Interactions, Receptor Competition, and Evidence for Synergistic Models
Framework for peptide combination research design: pharmacokinetic interactions (DPP-IV, neprilysin), receptor competition analysis (full vs partial agonists at shared receptor), and methodology for distinguishing additivity from synergy using Loewe combination index (CI) analysis.
Alpha Research
Stacks
GLOW Formulation: GHK-Cu + TB-500 + BPC-157 — Overlapping Angiogenic and Collagen Remodeling Pathways
GHK-Cu activates VEGF via Sp1, TB-500 via ILK/Akt/HIF-1α, and BPC-157 via eNOS/NO/PHD—creating a three-node angiogenic convergence. GHK-Cu balances MMP-1/TIMP and promotes collagen deposition; BPC-157 reinforces collagen biomechanical maturation via FAK/paxillin; TB-500 promotes endothelial and fibroblast migration via actin sequestration.
Alpha Research
Stacks
KLOW Formulation: KPV + GHK-Cu + TB-500 + BPC-157 — Mechanistic Rationale for Combinatorial Anti-Inflammatory and Repair Research
KPV inhibits NF-κB/ERK through intracellular penetration; GHK-Cu activates collagen synthesis via Sp1/MMP balance; TB-500 promotes migration and angiogenesis via actin sequestration/ILK/VEGF; BPC-157 activates FAK/Egr-1/eNOS. Combinatorial analysis evaluates anti-inflammatory redundancy and angiogenic convergence.
Alpha Research
Longevity
Melanocortin System Neuroanatomy: MC3R/MC4R Distribution, Second Messenger Cascades, and PT-141 Receptor Pharmacology
Detailed review of MC3R and MC4R neuroanatomical distribution in hypothalamic and limbic circuits, cAMP/PKA/CREB cascades downstream of receptor activation, and PT-141's pharmacological profile as a partial MC4R agonist with ~4-fold MC4R/MC3R Ki selectivity ratio.