Research
Scientific articles on peptide research, documentation, purity, and traceability.
Alpha Research
Longevity
Telomere Dynamics and Peptide Research: Epitalon, TERT Activation, and Telomerase-Directed Approaches
Review of telomere structure, the terminal replication problem, Epitalon's TERT activation mechanism (H3K9me3/H3K4me3 histone changes at the TERT promoter, TRAP assay, in vitro replicative lifespan extension), and telomeric heterochromatin maintenance via the SIRT6/NAD+ axis.
Alpha Research
Longevity
GABAergic and Serotonergic Modulation by Neuropeptides: Selank, Semax, and DSIP in Preclinical Anxiety Models
Selank indirectly modulates GABA-A through enkephalin aminopeptidase inhibition, Semax activates serotonergic turnover secondary to BDNF/TrkB, and DSIP modulates NMDAR and the HPA axis in preclinical anxiety models with EPM, Vogel, and SIH-specific parameters.
Alpha Research
Longevity
Neuropeptide Neurotransmission: Synthesis, Release, Receptor Specificity, and Research Differentiation from Classical Neurotransmitters
Neuropeptides are distinguished from classical neurotransmitters by dense-core vesicle synthesis, high-frequency release requirements, volume transmission, and exclusively GPCR signaling. Analysis of POMC processing, Y1R/Y2R/MC4R receptors, and research parameters.
Alpha Research
Longevity
Mitochondrial NAD+ Pools, Complex I Function, and Peptide Research Targeting the NAMPT/NMNAT Axis
Mitochondrial NAD+ pools are regulated by NMNAT3, distinct from cytoplasmic pools. Complex I requires NAD+ as hydride acceptor; its aging dysfunction links to NAMPT decline and PARP-1/CD38 substrate competition.
Alpha Research
Longevity
Longevity-Associated Peptides in 2026 Research: Telomerase Activation, Senolytic Mechanisms, and NAD+ Biology
Review of peptides with preclinical evidence across multiple aging pathways: Epitalon and TERT activation, SS-31 and mitochondrial preservation, BPC-157 and senescence reduction, and the role of NAD+ in SIRT6-mediated telomeric maintenance.
Alpha Research
Longevity
Peptides in Cognitive Research: BDNF/TrkB Signaling, Neuroplasticity Markers, and Preclinical Nootropic Data
Review of how peptides including Selank, Semax, BPC-157, and GHK-Cu modulate BDNF/TrkB signaling, induce neuroplasticity markers (Arc, synapsin-1, GluA1), and perform in preclinical memory models including MWM, NOR, and passive avoidance.
Alpha Research
Longevity
Selank vs Semax: Comparative Neuropeptide Profiles, Receptor Targets, and Cognitive Research Differentiation
Selank modulates GABA-A and induces BDNF; Semax activates ACTH/melanocortin pathways with effects on BDNF, dopamine, and hippocampal plasticity. Mechanistic comparison, anxiety vs cognition research models, and experimental parameters.
Alpha Research
Longevity
NAD+ Precursor Pharmacokinetics: Comparative Bioavailability of NR, NMN, and Direct NAD+ Formulations
NR enters cells via ENT1/2 and is phosphorylated to NMN intracellularly; NMN is transported via Slc12a8; direct NAD+ requires extracellular degradation. Comparative analysis of tissue kinetics, brain penetration, and research endpoints.
Alpha Research
Longevity
NAD+ Decline and Cellular Senescence: Hallmarks of Aging, Sirtuin Deacylation, and PARP-1/CD38 NAD+ Consumption Dynamics
NAD+ decline during aging is driven by hyperactivated PARP-1 (DNA damage repair), inflammatory CD38 overexpression, and NAMPT reduction, with consequences on SIRT1-7 activity that accelerate cellular aging hallmarks.
Alpha Research
Longevity
Bremelanotide (PT-141): MC3R/MC4R Agonism, Dopaminergic Pathway Activation, and Central Arousal Research Models
Bremelanotide is a melanocortin agonist with preferential selectivity for MC3R and MC4R that activates mesolimbic dopaminergic circuits in the medial preoptic area and hypothalamus, with preclinical data in central arousal models without direct peripheral action.
Alpha Research
Longevity
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro): GABA-A Modulation, BDNF Upregulation, and Anxiolytic Mechanism Research
Selank is a synthetic heptapeptide derived from tuftsin that modulates the GABA-A receptor, induces BDNF upregulation via TrkB, and demonstrates anxiolytic effects without sedation in rodent preclinical models with a profile distinct from benzodiazepines.
Alpha Research
Longevity
NAD+ (Nicotinamide Adenine Dinucleotide): Biosynthesis Pathways, CD38 Consumption, SIRT1-7 Activation, and Research Formulations
Review of the three NAD+ biosynthesis pathways (Preiss-Handler, Kynurenine, Salvage), CD38 as principal NAD+ consumer, and how NAD+ availability modulates SIRT1-7 sirtuins in preclinical aging and metabolic research models.